Development of CAR-T Therapy For Cancer In China
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Multiple Myeloma Therapy China, Bispecific BCMA/CD19 CAR-T Cell Therapy Opens New Era in the Treatment of Relapsed/Refractory Multiple Myeloma
Based on these data, a second-generation bispecific BC19 CAR targeting BCMA and CD19 was designed. This trial reports the preclinical results of BC19 CAR-T cells and the outcomes of R/R MM patients treated in the phase I/II trial.
2024 EBMT|Latest Data Disclosure on China's Harvesting of RRMM CAR-T Cell Therapy Equecabtagene Autoleucel (CT103a): Efficacy Unaffected by Patients' Baseline sBCMA Plasma Levels
During this EBMT meeting, Professor Qiu Lugui's team reported the latest subgroup analysis results from the FUMANBA-1 study (Abstract No. OS10-04) on B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor T (CAR-T) cell therapy for relapsed or refractory multiple myeloma (RRMM).
China's Second CAR-T Cell Therapy Zevorcabtagene Autoleucel (CT053) Approved for Treatment of Multiple Myeloma
Following the global launch of the first approved TIL cell therapy, lifileucel, the second CAR-T product in China for the treatment of multiple myeloma, Zevorcabtagene Autoleucel (赛恺泽), has finally received approval from the National Medical Products Administration (NMPA) for its new drug application to treat adult patients with relapsed or refractory multiple myeloma.
Successful Case of CAR-T Cell Therapy Equecabtagene Autoleucel (CT103A) Treatment in China
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Multiple Myeloma Chinese:High-Risk Multiple Myeloma Patient Achieves Cancer Cell Clearance in the First Month After CAR-T Therapy
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Hope Rekindled: The Remarkable Journey of a Pakistani Multiple Myeloma Patient in China
Hope Rekindled: The Remarkable Journey of a Pakistani Multiple Myeloma Patient in China [...
Multiple Myeloma Therapy From China
When All Treatment Options Were Exhausted, Cancer Rapidly Progressed, and the Doctor Regretfully Said That Ms. M Did Not Respond to Any Medication.
🔬✨ Overall Response Rate 50%! Chinese Research Entity's Solid Tumor CAR-T Hits Colorectal Cancer
🔬✨ Overall Response Rate 50%! Chinese Research Entity's Solid Tumor CAR-T Hits Colorectal Cancer ...
CAR-T products have been marketed worldwide
| Drug name | Price | Target point | Time to market | Research and development company | indication |
|---|---|---|---|---|---|
| Inaticabtagene Autoleucel(CNCT19) | 990,000 CNY | CD19 | 2023.11 | Juventas | the treatment of adult B-cell relapsed and refractory acute lymphoblastic leukemia (B-ALL). |
| Equecabtagene Autoleucel(FUCASO) | 1166,000 CNY | BCMA | 2023.7 | IASO BioTherapeutics | relapsed or refractory multiple myeloma who previously received 3 or more lines of therapy. |
| Carvykti | $465,000 | BCMA | 2022.2 | Legend Biotech | the treatment of adult patients with relapsed or refractory multiple myeloma after four or more prior lines of therapy. |
| Relmacabtagene Autoleucel(Carteyva) | 1290,000 CNY | CD19 | 2022.10 | JW Therapeutics | the treatment of adult patients with follicular lymphoma that is refractory or that relapses within 24 months of second-line or above systemic treatment (r/r FL). |
| Abecma | $438,000 | BCMA | 2021.3 | BristolMyers Squibb | Treat adult patients with multiple myeloma who have not responded to, or whose disease has returned after, at least four prior lines (different types) of therapy. |
| Axicabtagene ciloleucel(yescarta) | 1200,000 CNY | CD19 | 2021.6 | Fosun Kite | adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy |
| Breyanzi | $410,300 | CD19 | 2021.2 | BristolMyers Squibb | to treat adult patients with certain types of large B-cell lymphoma |
| Tecartus | $373,000 | CD19 | 2020.7 | Gilead Sciences | Relapsed or Refractory Mantle Cell Lymphoma |
| Yescarta | $373,000 | CD19 | 2017.10 | Kite Pharma | to treat adult patients with certain types of large B-cell lymphoma who have not responded to or who have relapsed after at least two other kinds of treatment. |
| Kymriah | $475,000 | CD19 | 2017.8 | Novartis | for certain pediatric and young adult patients with a form of acute lymphoblastic leukemia (ALL). |
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The US FDA approved the market of CAR-T
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CAR-T approved for market in China
1Whole-process management 1.Disease analysis
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6. Disease follow-up
7. Get insurance- 2Expert consultation assessment
1.Medical record collection
2.Translation of medical records
3.Text consultation
4.Video consultation - 3Ground access service
1. Apply for hospital invitation letter
2. Apply for a visa
3. Book a hotel
4. Airport pick-up and transportation
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6. Daily living assistance
7. Daily travel booking and assistance - 4Medical service
1. Designated hospitals are green
2. Assist in arranging examinations, hospitalization and treatment
3. Interpreter accompanied by hospital
4. Assist in issuing bills - 5CAR-T therapy
making a treatment plan1.CART cell technology Services
- 6Family accommodation
1. Based on 2 persons/month
2. Provide accommodation assistance to overseas personnel
- 1Whole-process management
1.Disease analysis 2. Create a file 3. Sorting out medical records 4. Preliminary assessment 5. Consult and arrange living assistance 6. Disease follow-up 7. Get insurance - 2Expert consultation assessment
1.Medical record collection 2.Translation of medical records 3.Text consultation 4.Video consultation - 3Ground access service
1. Apply for hospital invitation letter 2. Apply for a visa 3. Book a hotel 4. Airport pick-up and transportation 5. Mobile card processing 6. Daily living assistance 7. Daily travel booking and assistance
- 6Family accommodation
1. Based on 2 persons/month 2. Provide accommodation assistance to overseas personnel - 5CAR-T therapy
making a treatment plan
1.CART cell technology Services - 4Medical service
1. Designated hospitals are green 2. Assist in arranging examinations, hospitalization and treatment 3. Interpreter accompanied by hospital 4. Assist in issuing bills
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